diff --git a/docs/government.md b/docs/government.md
index 3350ef6c7..9cb0ecc5d 100644
--- a/docs/government.md
+++ b/docs/government.md
@@ -265,6 +265,16 @@ pageClass: routes
 
 </Route>
 
+### 指导原则专栏
+
+<Route author="TonyRL" example="/cde/zdyz/domesticGuide" path="/cde/zdyz/:category" :paramsDesc="['类别，见下表']" radar="1" rssbud="1">
+
+|      发布通告     |     征求意见    |
+| :-----------: | :---------: |
+| domesticGuide | opinionList |
+
+</Route>
+
 ## 国家自然科学基金委员会
 
 ### 基金要闻
diff --git a/lib/v2/cde/maintainer.js b/lib/v2/cde/maintainer.js
index 339d48cf0..70b33ae83 100644
--- a/lib/v2/cde/maintainer.js
+++ b/lib/v2/cde/maintainer.js
@@ -1,4 +1,5 @@
 module.exports = {
     '/xxgk/:category': ['TonyRL'],
+    '/zdyz/:category': ['TonyRL'],
     '/:channel/:category': ['Fatpandac'],
 };
diff --git a/lib/v2/cde/radar.js b/lib/v2/cde/radar.js
index ade8d0963..30763a5f3 100644
--- a/lib/v2/cde/radar.js
+++ b/lib/v2/cde/radar.js
@@ -56,6 +56,18 @@ module.exports = {
                 source: ['/main/xxgk/listpage/4b5255eb0a84820cef4ca3e8b6bbe20c'],
                 target: '/cde/xxgf/cliniCal',
             },
+            {
+                title: '发布通告 - 指导原则专栏',
+                docs: 'https://docs.rsshub.app/government.html#guo-jia-yao-pin-shen-ping-wang-zhan-shou-ye',
+                source: ['/main/xxgk/listpage/2853510d929253719601db17b8a9fd81'],
+                target: '/cde/zdyz/domesticGuide',
+            },
+            {
+                title: '征求意见 - 指导原则专栏',
+                docs: 'https://docs.rsshub.app/government.html#guo-jia-yao-pin-shen-ping-wang-zhan-shou-ye',
+                source: ['/main/xxgk/listpage/3c49fad55caad7a034c263cfc2b6eb9c'],
+                target: '/cde/zdyz/opinionList',
+            },
         ],
     },
 };
diff --git a/lib/v2/cde/router.js b/lib/v2/cde/router.js
index be1e651ae..2ab16c2dc 100644
--- a/lib/v2/cde/router.js
+++ b/lib/v2/cde/router.js
@@ -1,4 +1,5 @@
 module.exports = function (router) {
     router.get('/xxgk/:category', require('./xxgk'));
+    router.get('/zdyz/:category', require('./zdyz'));
     router.get('/:channel/:category', require('./index'));
 };
diff --git a/lib/v2/cde/zdyz.js b/lib/v2/cde/zdyz.js
new file mode 100644
index 000000000..90bbacd8a
--- /dev/null
+++ b/lib/v2/cde/zdyz.js
@@ -0,0 +1,77 @@
+const got = require('@/utils/got');
+const cheerio = require('cheerio');
+const { parseDate } = require('@/utils/parse-date');
+const utils = require('./utils');
+
+const baseUrl = 'https://www.cde.org.cn';
+const zdyzMap = {
+    zdyz: {
+        domesticGuide: {
+            title: '发布通告',
+            url: `${baseUrl}/zdyz/listpage/2853510d929253719601db17b8a9fd81`,
+            endPoint: '/zdyz/getDomesticGuideList',
+            form: {
+                pageNum: 1,
+                pageSize: 10,
+                searchTitle: '',
+                isFbtg: 1,
+                classid: '2853510d929253719601db17b8a9fd81',
+                issueDate1: '',
+                issueDate2: '',
+            },
+        },
+        opinionList: {
+            title: '征求意见',
+            url: `${baseUrl}/main/zdyz/listpage/3c49fad55caad7a034c263cfc2b6eb9c`,
+            endPoint: '/zdyz/getOpinionList',
+            form: {
+                pageNum: 1,
+                pageSize: 10,
+                searchTitle: '',
+                issueDate1: '',
+                issueDate2: '',
+                fclass: '征求意见',
+            },
+        },
+    },
+};
+
+module.exports = async (ctx) => {
+    const { category } = ctx.params;
+
+    const { data } = await got.post(`${baseUrl}${zdyzMap.zdyz[category].endPoint}`, {
+        form: zdyzMap.zdyz[category].form,
+        headers: {
+            referer: zdyzMap.zdyz[category].url,
+            cookie: await utils.getCookie(ctx),
+        },
+    });
+
+    const list = data.data.records.map((item) => ({
+        title: item.title,
+        pubDate: parseDate(item.issueDate),
+        link: item.externalLinks,
+    }));
+
+    const items = await Promise.all(
+        list.map((item) =>
+            ctx.cache.tryGet(item.link, async () => {
+                const response = await got(item.link, {
+                    headers: {
+                        referer: zdyzMap.zdyz[category].url,
+                        cookie: await utils.getCookie(ctx),
+                    },
+                });
+                const $ = cheerio.load(response.data);
+                item.description = $('.new_detail_content').html() + $('.relatedNews').html();
+                return item;
+            })
+        )
+    );
+
+    ctx.state.data = {
+        title: `${zdyzMap.zdyz[category].title} - 国家药品监督管理局药品审评中心`,
+        link: zdyzMap.zdyz[category].url,
+        item: items,
+    };
+};